Dietary Intake and Ovarian Cancer Risk: A Systematic Review
This review suggests that no specific dietary factors are consistently associated with ovarian cancer risk. Data by tumor subtypes are limited, but suggest that differential associations by tumor subtype may exist and should be evaluated. Studies of ample sample size, varied exposure, which can better control for dietary measurement error, are needed to fully define dietary recommendations for ovarian cancer prevention. Crane TE, Khulpateea BR, Alberts DS, Basen-Engquist K, Thomson CA. Cancer Epidemiol Biomarkers Prev. 2013 Oct 18. [Epub ahead of print] PMID: 24142805
Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin
Over 102 weeks, dapagliflozin improved glycaemic control, and reduced weight and fat mass, without affecting markers of bone turnover or BMD in patients with T2DM inadequately controlled on metformin. Evidence Updates
OnabotulinumtoxinA 100 U significantly improves all idiopathic overactive bladder symptoms and quality of life in patients with overactive bladder and urinary incontinence: a randomised, double-blind, placebo-controlled trial
OnabotulinumtoxinA 100 U was well tolerated and demonstrated significant and clinically relevant improvements in all OAB symptoms, patient-reported benefit, and HRQOL in patients inadequately managed by anticholinergics. Evidence Updates
Metoclopramide in Pregnancy and Risk of Major Congenital Malformations and Fetal Death
Metoclopramide use in pregnancy was not associated with increased risk of major congenital malformations overall, any of the 20 individual malformation categories assessed, spontaneous abortion, or stillbirth. These safety data may help inform decision making when treatment with metoclopramide is considered in pregnancy. Evidence Updates
Effects of high and low fat dairy food on cardio-metabolic risk factors: a meta-analysis of randomized studies
Increasing whole fat and low fat dairy food consumption increases weight but has minor effects on other cardio-metabolic risk factors. Benatar JR, Sidhu K, Stewart RA. PLoS One. 2013 Oct 11;8(10):e76480. PMID: 24146877
Primary closure versus delayed closure for non bite traumatic wounds within 24 hours post injury.
There is currently no systematic evidence to guide clinical decision-making regarding the timing for closure of traumatic wounds. There is a need for robust research to investigate the effect of primary closure compared with delayed closure for non bite traumatic wounds presenting within 24 hours of injury. Eliya-Masamba MC, Banda GW. Cochrane Database Syst Rev. 2013 Oct 22;10:CD008574. [Epub ahead of print] PMID: 24146332
Treatment of vaginal bleeding irregularities induced by progestin only contraceptives
Some women may benefit from the interventions described, particularly with cessation of current bleeding. Several regimens offer promise in regulating bleeding, but findings need to be reproduced in larger trials. The results of this review do not support routine clinical use of any of the regimens included in the trials, particularly for long-term effect. Abdel-Aleem H, d'Arcangues C, Vogelsong KM, Gaffield ML, Gülmezoglu AM. Cochrane Database Syst Rev. 2013 Oct 21;10:CD003449. [Epub ahead of print] PMID: 24146298
Screening, Monitoring, and Treatment of Stage 1 to 3 Chronic Kidney Disease: A Clinical Practice Guideline From the Clinical Guidelines Committee of the American College of Physicians
The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on the screening, monitoring, and treatment of adults with stage 1 to 3 chronic kidney disease. Qaseem A, Hopkins RH, Sweet DE, Starkey M, Shekelle P. Ann Intern Med. 2013 Oct 22. [Epub ahead of print] PMID: 24145991
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