Reviews

Fixed-dose combination antituberculosis therapy: a systematic review and meta-analysis
There was a trend toward higher risk of failure or relapse with FDC (pooled relative risk 1.28 (95% CI 0.99-1.7)). Based on individual study results, only one of two trials that assessed treatment satisfaction, and none of five that assessed patient adherence, favoured FDCs. Although FDC formulations simplify TB therapy, the current evidence does not indicate that these formulations improve treatment outcomes among patients with active TB. Evidence Updates

Microalbuminuria as a risk factor for cardiovascular disease in healthy individuals: a case report and review of the literature
Microalbuminuriais a risk factor commonly overlooked despite evidence of being an independent marker for cardiovascular disease. We report a case of a myocardial infarction occurring in an otherwise healthy 64-year-old male with microalbuminuria, without traditional cardiovascular risk factors. Awareness of microalbuminuria as an early diagnostic marker for cardiovascular disease (CVD) is essential in the risk assessment of otherwise healthy individuals. Noyes AM, Eckardt K. Conn Med. 2013 Aug;77(7):399-402. PMID: 24195177

Ruboxistaurin for the treatment of diabetic peripheral neuropathy: a systematic review of randomized clinical trials
RBX had effects on DPN in some studies, but the evidence is not enough for meta-analysis and firm conclusion. Bansal D, Badhan Y, Gudala K, Schifano F. Diabetes Metab J. 2013 Oct;37(5):375-84. doi: 10.4093/dmj.2013.37.5.375. Epub 2013 Oct 17. PMID: 24199167