Oral high-dose multivitamins and minerals after myocardial infarction: a randomized trial
High-dose oral multivitamins and multiminerals did not statistically significantly reduce cardiovascular events in patients after MI who received standard medications. However, this conclusion is tempered by the nonadherence rate. Lamas GA, Boineau R, Goertz C, Mark DB, Rosenberg Y, Stylianou M, Rozema T, Nahin RL, Lindblad L, Lewis EF, Drisko J, Lee KL; TACT (Trial to Assess Chelation Therapy) Investigators. Ann Intern Med. 2013 Dec 17;159(12):797-805. PMID: 24490264
In elderly subjects at high CV risk without established CV disease, statins significantly reduce the incidence of MI and stroke, but do not significantly prolong survival in the short-term. Savarese G, Gotto AM Jr, Paolillo S, D'Amore C, Losco T, Musella F, Scala O, Marciano C, Ruggiero D, Marsico F, De Luca G, Trimarco B, Perrone-Filardi P. J Am Coll Cardiol. 2013 Dec 3;62(22):2090-9. Epub 2013 Aug 28. PMID: 23954343
Psychological treatments for depression and anxiety in dementia and mild cognitive impairment
We found evidence that psychological interventions added to usual care can reduce symptoms of depression and clinician-rated anxiety for people with dementia. We conclude that psychological interventions have the potential to improve patient well-being. Further high quality studies are needed to investigate which treatments are most effective and to evaluate the effect of psychological interventions in people with MCI. Orgeta V, Qazi A, Spector AE, Orrell M. Cochrane Database Syst Rev. 2014 Jan 22;1:CD009125. PMID: 24449085
Combination contraceptives: effects on weight
Available evidence was insufficient to determine the effect of combination contraceptives on weight, but no large effect was evident. Trials to evaluate the link between combination contraceptives and weight change require a placebo or non-hormonal group to control for other factors, including changes in weight over time. Gallo MF, Lopez LM, Grimes DA, Carayon F, Schulz KF, Helmerhorst FM. Cochrane Database Syst Rev. 2014 Jan 29;1:CD003987. PMID: 24477630
Ultrasonography Screening for Abdominal Aortic Aneurysms: A Systematic Evidence Review for the U.S. Preventive Services Task Force
One-time invitation for AAA screening in men aged 65 years or older was associated with decreased AAA rupture and AAA-related mortality rates but had little or no effect on all-cause mortality rates. Guirguis-Blake JM, Beil TL, Senger CA, Whitlock EP. Ann Intern Med. 2014 Jan 28. [Epub ahead of print] PMID: 24473919
Elective birth at 37 weeks' gestation for women with an uncomplicated twin pregnancy
Early birth at 37 weeks' gestation compared with ongoing expectant management for women with an uncomplicated twin pregnancy does not appear to be associated with an increased risk of harms, findings which are consistent with the United Kingdom's National Institute for Health and Care Excellence (NICE) recommendations which advocate birth for women with a dichorionic twin pregnancy at 37 + 0 weeks' gestation. It is unlikely that sufficient clinical equipoise exists to allow for the randomisation of women to a later gestational age at birth. Dodd JM, Deussen AR, Grivell RM, Crowther CA. Cochrane Database Syst Rev. 2014 Feb 10;2:CD003582. [Epub ahead of print] PMID: 24510739
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