Dr. Sydney Burwell, Dean of Harvard Medical School 1956

My students are dismayed when I say to them "Half of what you are taught as medical students will in 10 years have been shown to be wrong.
And the trouble is, none of your teachers know which half."



Monday, March 3, 2014

Reviews

Cost-effectiveness of cognitive-behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care: economic evaluation of the CoBalT Trial
The addition of CBT to usual care is cost-effective in patients who have not responded to antidepressants. Primary care physicians should therefore be encouraged to refer such individuals for CBT. Hollinghurst S, Carroll FE, Abel A, Campbell J, Garland A, Jerrom B, Kessler D, Kuyken W, Morrison J, Ridgway N, Thomas L, Turner K, Williams C, Peters TJ, Lewis G, Wiles N.
Br J Psychiatry. 2014 Jan;204(1):69-76.Epub 2013 Nov 21. PMID: 24262818
Risk of drug-induced liver injury with the new oral anticoagulants: systematic review and meta-analysis
NOACs are not associated with an increased risk of DILI. The unexpected 'protective' effect of NOAC is probably due to LMWH-associated hepatotoxicity. Caldeira D, Barra M, Santos AT, de Abreu D, Pinto FJ, Ferreira JJ, Costa J. Heart. 2014 Jan 29. [Epub ahead of print] PMID: 24476812

Vegetarian Diets and Blood Pressure: A Meta-analysis
Consumption of vegetarian diets is associated with lower BP. Such diets could be a useful nonpharmacologic means for reducing BP. Yokoyama Y, Nishimura K, Barnard ND, Takegami M, Watanabe M, Sekikawa A, Okamura T, Miyamoto Y. JAMA Intern Med. 2014 Feb 24. [Epub ahead of print] PMID: 24566947

Effectiveness of general practice-based health checks: a systematic review and meta-analysis
General practice-based health checks are associated with statistically significant, albeit clinically small, improvements in surrogate outcome control, especially among high-risk patients. Most studies were not originally designed to assess mortality. Si S, Moss JR, Sullivan TR, Newton SS, Stocks NP. Br J Gen Pract. 2014 Jan;64(618):e47-53. PMID: 24567582
The influence of regular walking at different times of day on blood lipids and inflammatory markers in sedentary patients with coronary artery disease
Our walking program successfully resulted in a favorable change in lipids and inflammatory markers. Patients in the evening walking group gained more benefits than those walking in the morning walking group. Lian XQ, Zhao D, Zhu M, Wang ZM, Gao W, Zhao H, Zhang DG, Yang ZJ, Wang LS. Prev Med. 2014 Jan;58:64-9. Epub 2013 Nov 4. PMID: 24201089
A trial of treatment for acute otorrhea in children with tympanostomy tubes
Antibiotic-glucocorticoid eardrops were more effective than oral antibiotics and initial observation in children with tympanostomy tubes who had uncomplicated acute otorrhea. van Dongen TM, van der Heijden GJ, Venekamp RP, Rovers MM, Schilder AG. N Engl J Med. 2014 Feb 20;370(8):723-33. PMID: 24552319

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